Derwent Drug File Database Guide
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Derwent Drug File is the definitive source of drug journal and conference information on all aspects of drug development, synthesis, evaluation, manufacture and use. The unique indexing of this information enables you to search quickly and precisely for new developments in your field, or from key competitors. In addition, the unique combination of biological and chemical information is ideal for exploring all types of structure-activity relationships. An estimated 20% of the data in Derwent Drug File is not available in any other drug database. Drug structure GIFs are available to Ovid Web users.

Segments and Years of Coverage
Name   Years of Coverage
DERD   1964 - present
DERD1   1964 - 1989
DERD2   1990 - 1999
DERD3   2000 - present

The limit of databases that you can select for a multifile search session is based upon database segments rather than actual databases. The Ovid multifile segment limit is set at 120 to avoid impacting your search sessions. This database includes 3 segments.

This database is updated online weekly.

Fields
The following list is sorted alphabetically by field alias. Click a field name to see the description and search information.
All Fields in this Database
  Abstract (AB) Heading Word (HW) Profile Section (PS)
  Accession Number (AN) ISSN (IS) Reprint Address (RA)
  All Searchable Fields (AF) Issue/Part (IP) Source (SO)
  Author (AU) Journal Name (JN) Subject Heading (SH)
  Coden (CD) Journal Word (JX) Subject Terms (ST)
  Common Terms (CT) Language (LG) Thematic Groups (TG)
  Conference Information (CF) Linked Terms (LT) Title (TI)
  Corporate Affiliates (CA) Linked Terms Words (LW) Update Code (UP)
  Corporate Information (CI) Local Messages (LM) Volume (VO)
  Date Delivered (DD) Location of Corporation (LO) Year (YR)
  Derwent Registry Name (DR) Original Title (OT)  
  Floating Subheadings (FS) Page (PG)  
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Default Fields for Unqualified Searches (MP): Searching for a term without specifying a field in Advanced search, or specifying .mp., defaults to the following ‘multi-purpose’ (.mp.) fields for this database: ti,hw,ab.
  Abstract (AB) Heading Word (HW) Title (TI)
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Default Fields for Display, Print, Email, and Save: The following fields are included by default for each record.

  Abstract (AB) Corporate Information (CI) Source (SO)
  Accession Number (AN) Language (LG) Subject Terms (ST)
  Coden (CD) Linked Terms (LT) Thematic Groups (TG)
  Common Terms (CT) Location of Corporation (LO) Title (TI)
  Conference Information (CF) Profile Section (PS) Update Code (UP)
  Corporate Affiliates (CA) Reprint Address (RA)  
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All Fields for Display, Print, Email, and Save: Use the Select Fields button in the Results Manager at the bottom of the Main Search Page to choose the fields for a record.

  Abstract (AB) Derwent Registry Name (DR) Source (SO)
  Accession Number (AN) ISSN (IS) Subject Heading (SH)
  Author (AU) Language (LG) Subject Terms (ST)
  Coden (CD) Linked Terms (LT) Thematic Groups (TG)
  Common Terms (CT) Local Messages (LM) Title (TI)
  Conference Information (CF) Location of Corporatation (LO) Update Code (UP)
  Corporate Affiliates(CA) Original Title (OT) Year (YR)
  Corporate Information (CI) Profile Section (PS)  
  Date Delivered (DD) Reprint Address (RA)  
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Elements of Source (SO) Field: Ovid searches the following fields as part of the record source.
  Issue/Part (IP) Page (PG) Year (YR)
  Journal Name (JN) Volume (VO)  
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The following list is sorted alphabetically by the two-letter label, and includes the relevant alias, at least one example for all searchable fields, and a description of the field.
Label Name / Example
AB Abstract [Word Indexed]
anaphylactic shock.ab.
 

The Abstract (AB) field is a concise abstract, generally around 90 words, which summarizes all the important qualitative data in the original article. This abstract is not identical to the author's abstract which is found in other databases. It is written by subject specialists at Derwent to highlight the important aspects of the drugs which may not be disclosed in the author's abstract.

The field contains the Derwent abstract and the extended abstract with Methods and Results when available. Reference, Figure, and Table information will also be found at the end of the field when available.

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AF All Searchable Fields [Search Alias]
heart.af.
  All Fields (AF) is an alias for all of the fields which occur in the source documents, including value-added fields such as Abstract (AB).
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AN Accession Number [Phrase Indexed]
2002-00004.an.
  The Accession Number (AN) field contains a unique sequential nine-digit number assigned to each document. You can retrieve article by searching with or without a hyphen: 2003-07293.an. or "2003 07293".an.
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AU Author [Phrase Indexed]
Smith A B.au.
 

The Author (AU) field contains the names of individual authors, editors or compilers. Individual author names appear as last name followed by one or more initials (Smith A B) and should be searched without using periods.

The Author (AU) index is browsable.
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CA Corporate Affiliates [Phrase Indexed]
gacell.ca.
 

The Corporate Affiliates (CA) index contains the name of the company, university or research institute for which the authors were working. Derwent provides only abbreviations of these names but the index is browsable.

This field also displays in the Corporate Information (CI) field.

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CD Coden [Phrase Indexed]
VHTODE.cd.
  The Coden (CD) field contains the journal Coden. This is either the standard coden for the journal, or if the journal did not have one, the coden is made by Derwent.
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CF Conference Information [Word Indexed]
224th ACS National Meeting.cf.
  The Conference Information (CF) field includes the name, location, and year in which the conference was held. This information is only available from 1998 onward.
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CI Corporate Information [Word Indexed]
Nat Cancer Inst Bethesda.ci.
 

The Corporate Information (CI) field contains the company, university or research institute name and location at which the author was working.

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CT Common Terms [Word Indexed]
"Diabetes/OC".ct.
"Lab.animal/ft".ct.
"ft".ct.
 

The Common Terms (CT) field contains the keywords relating to the all of the drugs being discussed in the record. The keywords and their roles are searchable together or seperate. The Roles are as follows:

Adverse Effects AE   Drug Interaction DI
Drug Metabolism DM   Further Terms FT
Other Context OC   Pharmacology PH
Reference Compound RC   Treatment TR

It is important to note that diseases are only indexed with Adverse Effects (AE), Other Context (OC), and Treatment (TR), but drugs are indexed with all. If appropriate, more than one role may be assigned to a term and the same role may be assigned to multiple terms.

The CT index is browsable.

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DD Date Delivered [Phrase Indexed]
20161125.dd.
limit 1 to dd=20160902-20161111
  The Date Delivered (DD) field is the date the record was added into a Derwent database.

You can retrieve articles by date range by limiting any search to "limit 1 to dd=YYYYMMDD-YYYYMMDD".

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DR Derwent Registry Name [Phrase Indexed]
pentobarb.dr.
  The Derwent Registry Name (DR) is the unique name assigned by Derwent to the drug being cited.
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FS Floating Sub-Heading [Phrase Indexed]
ph.fs.
 

The Floating Subheadings (FS) index contains the 2-letter codes, such as "ae". These are displayed following the corresponding Subject Headings.

Subheadings are qualifiers added to subject headings to refine their meaning. Terms such as "Adverse Effects" or "Treatment", when combined with a heading, give a precise idea of what an article covers.

Adverse Effects (AE)
Drug Interaction (DI)
Drug Metabolism (DM)
Further Terms (FT)
Other Context (OC)
Pharmacology (PH)
Reference Compound (RC)
Treatment (TR)
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HW Heading Word [Word Indexed]
shock.hw.
 

The Heading Word (HW) index contains all the keywords found in the Common Terms (CT), Linked Terms (LT), and pre-1983 Subject Terms (ST) fields.

This index displays in the Subject Headings (SH) or Subject Terms (ST) fields.

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IP Issue/Part [Word Indexed]
no 5.ip.
 

The Issue/Part (IP) field contains the issue or part number of the journal in which the article was printed. Prior to 2002, this information was not always included in the Derwent record.

This field displays as part of the Source (SO) field.

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IS ISSN [phrase Indexed]
0001-5172.is.
  The ISSN (IS) field contains the International Standard Serial Number (ISSN) for the journal in which an article was published. It is only available from Derwent for 1983 onward.
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JN Journal Name [Phrase Indexed]
molecular cancer research.jn
 

The Journal Name (JN) index contains both full and abbreviated name of the journal in which the article was published. This data is only consistently available from 1983 onward.

The JN index is browsable.
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JX Journal Word [Word Indexed]
immunology.jx
 

The Journal Word (JX) index contains individual title words from the full journal name and is aliased to JW.

Journal names display in the Source (SO) field.

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LG Language [Phrase Indexed]
english.lg.
 

The Language (LG) field contains the original language or languages of the document.

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LM Local Messages [Display Only]
 

The Local Messages (LM) field contains messages created by the System Administrator to indicate information about journals held in your local library system.

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LO Location of Corporation [Word Indexed]
japan.lo.
 

The Locations (LO) index contains the location of the company, university or research institute for which the authors were working. Derwent provides only abbreviations of these locations.

This field also displays in the Corporate Information (CI) field.

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LT

Linked Terms [Phrased Indexed]
p 450.lt

 

The Linked Terms (LT) field contains each drug being discussed in the record and the keywords relating to that drug. There can be more than one drug discussed in each record. If this is the case, they are designated by number.

The LT keywords are indexed as phrases with the appropriate Roles (also known as subheadings) attached with a limit of 250 characters.

Adverse Effects   AE   Drug Role: Drugs causing adverse events in humans and animals, including clinical side effects and animal toxicology (LD50 etc.).
Disease Role: Adverse events and side effects, diseases in animals and humans caused by drugs.
Drug Interactions   DI   Drug Role: Drug interactions, for example, synergism, biological or physical (pharmaceutical) incompatibility.
Drug Metabolism   DM   Drug Role: Drug metabolism, for example, pharmacokinetics, bioavailability, or transformation.
Further Terms   FT   Further Term, used for everything that isn't a drug name or a disease name. Includes endogenous compounds, test systems, organism names, standard drug classes (higher terms) and activities.
Examples:
INSULIN/TR - for therapy with insulin
INSULIN/FT - for references to endogenous insulin (such as plasma levels)
Other Context   OC   Drug Role: Other context - a context not covered by another role, including chem istry and synthesis, analysis and pharmaceutics. For example, references to galenical incompatibility would be found using OC and DI as the drug roles.
Disease Role: Diseases in humans not being treated and not occurring as a side effect, and animal models of disease.
Pharmacology   PH   Drug Role: Pharmacology in humans, animals and isolated organs, cells and tissue cultures.
Reference Compound   RC   Drug Role: Reference compound, drugs of secondary importance such as standards and reagents. (Reference compounds are not assigned to their own LT field but appear in the LT field of the drug they refer to. Higher terms, CAS numbers etc. are not posted for references compounds).
Treatment   TR   Drug Role: Drugs treating diseases in humans (not animals - use PH).
Disease Role: Diseases being treated in humans (not animals - use OC).

Note: Diseases are only indexed with AE, OC, and TR, but drugs are indexed with all. If appropriate, more than one role may be assigned to a term and the same role may be assigned to multiple terms.

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LW Linked Terms Words [Word Indexed]
abacavir.lw.
 

The Linked Terms Words (LW) contain individual drug terms being discussed in the record and the keywords relating to that drug.

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OT Original Title [Word Indexed]
aanbevolen.ot.
  The Original Title (OT) includes any non-English titles in the original language. If the original title was in a non-Roman alphabet, then the OT is transliterated.
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PG Page [Word Indexed]
274.pg.
 

The Page (PG) field contains the page numbers for the journal where the article is found. Prior to 2002, this information was not always included in the Derwent record.

This field displays as part of the Source (SO) field.

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PS Profile Section [Phrase Indexed]
adverse reactions.ps.
  The Profile Section (PS) field contains one or more of 54 drug-related topics based on subjects in the abstract. These are very useful for general concept searching.
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RA Reprint Address [Display Only]
  The Reprint Address (RA) field contains the address for further inquiries.
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SH Subject Heading [Phrase Indexed]
influenza-virus.sh.
"ft".sh.
  The Subject Heading (SH) field contains all of the keywords and roles which are in the thesaurus. These keywords and roles can be also found in the Common Terms (CT) and Linked Terms (LT) fields. Subject Heading terms prior to 1983 are found the Subject Terms (ST) field.
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SO Source [Display Only]
 

The Source (SO) field combines the name of the journal, volume, issue, pages and year in standard format.

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ST Subject Terms [Word Indexed]
w256.st.
  The Subject Terms (ST) field contains the old Derwent subject heading terms for the record. This field only appears in pre 1983 records.
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TG Thematic Groups [Phrase Indexed]
pharmacology.tg.
adverse effects.tg.
vitamins.tg
 

The Thematic Group (TG) field contains classification terms applied by Derwent analysts that relate to a broad area of study. It can be searched by the Group letter or full Term.

A   Analysis       H   Herbicides       T   Therapeutics
B   Biochemistry   L   Legislation   V   Vitamins
C   Chemistry   M   Microbiology   W   Veterinary Medicine
D   Diagnosis   N   Nutrition   X   Mathematics
E   Endocrinology   P   Pharmacology   Z   Zoology
G   Galenics   S   Adverse Effect        
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TI Title [Word Indexed]
infarction.ti.
  The Title (TI) field contains the original authors' title when in English. Otherwise, it is a translation into English made by Derwent together with an indication of the original language.
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UP Update Code [Phrase Indexed]
200700.up.
201607.up.
 

The Update Code (UP) field consists of the 6 digit date for new records. The date is comprised of the year and the week. Example: 201512.

Prior to the 2016 reload the update code will be only the year and '00'.
Example: 199900.

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VO Volume [Word Indexed]
103.vo.
  The Volume (VO) index consists of the volume number of a journal. Prior to 2002 this information was not always included in the Derwent record. The Volume field displays as part of the Source (SO) field.
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YR Year [Phrase Indexed]
2001.yr.
  The Year (YR) field contains the year in which the article was published. This field displays as part of the Source (SO) field.
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Advanced Searching
You can use special search syntax listed below to combine search terms or strategically develop a search. Full documentation is provided in the Advanced Searching Techniques section of the Online Help.
Operator Syntax Search Example Sample Results
OR x or y analgesics or side effects

"Side effects of oral misoprostol"

 

The OR operator retrieves records that contain any or all of the search terms. For example, the search heart attack or myocardial infarction retrieves results that contain the terms heart attack, myocardial infarction or both terms; results are all inclusive. You can use the OR operator in both unqualified searches and searches applied to a specific field.
AND x and y analgesics and adverse effects

"most common adverse effects observed during i.v. Ig therapy were headaches (n = 5) and nausea (n = 2), which were controlled with p.o. analgesics and antiemetics"

 

The AND operator retrieves only those records that include all of the search terms. For example, the search blood pressure and stroke retrieves results that contain the term blood pressure and the term stroke together in the same record; results are exclusive of records that do not contain both of these terms. You can use the AND operator in both unqualified searches and searches applied to a specific field.
NOT x not y analgesics not aspirin

"Topical, targeted delivery of analgesics using Transfersomes"

 

The NOT operator retrieves records that contain the first search term and excludes the second search term. For example, the search health reform not health maintenance organizations retrieves only those records that contain the term health reform but excludes the term health maintenance organizations. In this way, you can use the NOT operator to restrict results to a specific topic.
You can use the NOT operator in both unqualified searches and searches applied to a specific field.
Adjacency (ADJ) x y glutamatergic receptors

"involvement of glutamatergic receptors in the antinociception"

 

The Adjacent operator (ADJ) retrieves records with search terms next to each other in that specific order. You do not need to separate search terms manually by inserting ADJ between them, because when you separate terms with a space on the command line, Ovid automatically searches for the terms adjacent to one another. For example, the search blood pressure is identical to the search blood adj pressure.
CheckTags
 

CheckTags are frequently searched terms that have been identified to bypass the mapping screen to help the searcher get to the results faster. Derwent Drug File checktags terms includes the following:

AE CASES
DI IN-VIVO
DM IN-VITRO
FT CLIN.TRIAL
OC BLIND-TEST
PH BLOOD-PLASMA
RC CYTOSTATIC
RN CYTOSTATICS
TR PLACEBO
ST RANDOM
Defined Adjacency (ADJn) x ADJn y adverse adj3 side-effect

"Side-effect endpoints were adverse events at least 20%"

 

The defined adjacency operator (ADJn) retrieves records that contain search terms within a specified number (n-1) of words from each other in any order (stop-words included). To use the adjacency operator, separate your search terms with ADJ and a number from 1 to 99 as explained below:

           ADJ1     Next to each other, in any order
           ADJ2     Next to each other, in any order, up to 1 word in between
           ADJ3     Next to each other, in any order, up to 2 words in between
           ADJ99   Next to each other, in any order, up to 98 words in between

For example, the search physician adj5 relationship retrieves records that contain the words physician and relationship with a maximum of four words in between in either direction. This particular search retrieves records containing such phrases as physician patient relationship, patient physician relationship, or relationship between cancer patient and physician.
Please note Ovid’s order of operation handles terms within parentheses first. Therefore it is recommended to apply the ADJn operator in one-on-one operations to avoid missing out on results. E.g. stroke adj4 (blood pressure or high blood pressure) could potentially miss out on some combinations of stroke with high blood pressure. The optimum way to execute this on Ovid is: (stroke adj4 blood pressure) OR (stroke adj4 high blood pressure).
Frequency (FREQ) x.ab./FREQ=n blood.ab./freq=5

"creatinine using capillary blood was developed using finger prick venous and capillary blood samples"

 

The frequency operator (FREQ) lets you specify a threshold of occurrence of a term in the records retrieved from your search. Records containing your search term are retrieved only if the term occurs at least the specified (n) number of times. In general, records that contain many instances of your search term are more relevant than records that contain fewer instances. The frequency operator is particularly useful when searching a text field, such as Abstract or Full Text, for a common word or phrase.
Unlimited Truncation ($) x$

rat$

"Calibrated serological techniques"

 

Unlimited truncation retrieves all possible suffix variations of the root word indicated. To apply unlimited truncation to a term, type the root word or phrase followed by either of the truncation characters: $ (dollar sign) or * (asterisk). For example, in the truncated search rat*, Ovid retrieves the word rat as well as the words rats, and more.
Limited Truncation ($) x$n

dog$1

"beta-adrenergic stimulation in conscious dogs"

 

Limited truncation specifies a maximum number of characters that may follow the root word or phrase. For example, the truncated search dog$1 retrieves results with the words dog and dogs; but it does not retrieve results with the word dogma.
Mandated Wildcard (#) xx#y

wom#n

"postmenopausal women with type 2 diabetes mellitus"

 

Searching with a mandated wildcard retrieves all possible variations of a word in which the wildcard is present in the specified place. You can use it at the end of a term to limit results to only those that contain the word plus the mandated character. For example, the search dog# retrieves results that contain the word dogs, but not those that contain the word dog, effectively limiting results to only those that contain the plural form of the word. The mandated wild card character (#) is also useful for retrieving specialized plural forms of a word. For example, the search wom#n retrieves results that contain both woman and women. You can use multiple wild cards in a single query word.
Optional Wildcard (?) xx?y colo?r

"growth of colon cancer cells"

 

The optional wild card character (?) can be used within or at the end of a search term to substitute for one or no characters. This wild card is useful for retrieving documents with British and American word variants since it specifies that you want retrieval whether or not the extra character is present. For example, the optional wild card search colo?r retrieves results that contain the words color or colour. You can use multiple wild cards in a single query word.
Literal String ("") "x / y" "hot and cold"

"feeling hot and cold, malaise"

"n" "3".vo

"HIV Medicine (3, No. 4, 277-82, 2002)"

 

Quotation marks can be used to retrieve records that contain literal strings, when the string includes special characters, such as a forward slash (/).

Quotation marks can also be used to retrieve records that contain numbers that may otherwise be confused for earlier searches. In the example, a search for 3.vo would limit the string from your third search in your search history to the volume field. By including the number in quotation marks, the search will retrieve documents with a 3 in the volume number.

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Stopwords

The Ovid search engine applies so called "run-time stopword processing". This means the search engine on the fly ignores the stopwords: and, as, by, for, from, in, is, of, on, that, the, this, to, was, were & with.

Therefore a search: at risk for diabetes.ti will also find: at risk of diabetes. The distance of one word in between is kept, but the stopword "for" is ignored.

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Limits
The following limits are available for this database. See Database Limits in the Ovid Online Help for details on applying limits.

Limit

Syntax
Animal Sentence Syntax: limit 1 to animal
  A limit to Animal restricts retrieval to documents which are primarily about animal subjects. Articles about both animal and human subjects are retained.
Cases Sentence Syntax: limit 1 to cases
  A limit to Cases restricts retrieval to documents which are case studies of a drug.
Clinical Trial Sentence Syntax: limit 1 to clinical trial
  A limit to Clinical Trial will restrict retrieval to documents describing clinical trials of any drug.
Conference Sentence Syntax: limit 1 to conference
  A limit to Conference restricts retrieval to Conference records only.
English Language Sentence Syntax: limit 1 to english language
  A limit to English Language restricts retrieval to documents in english only.
Female Sentence Syntax: limit 1 to female
  A limit to Female restricts retrieval to documents which are about females, both animal and human.
Full text Sentence Syntax: limit 1 to full text
  A limit to Full Text will result in only those records that have links to full text. Both Ovid full text and external full text are included in this limit.
Human Sentence Syntax: limit 1 to human
  A limit to Human restricts retrieval to documents which are primarily about human subjects. Articles about both human and animal subjects are retained.
Image Sentence Syntax: limit 1 to image
  A limit to Image restricts retrieval to documents containing an image of the drug(s) chemical structure. This option is only available on the Web.
Lab Animal Sentence Syntax: limit 1 to lab animal
  A limit to Lab Animal will restrict retrieval to documents which contain lab animals as part of the study.
Language Sentence Syntax: limit 1 to french
  A limit to Language restricts retrieval to any of the languages found in Derwent records. This limit does not bring up every document with the language, as some of the older records do not have a language field.
Latest Update Sentence Syntax: limit 1 to latest update
  A limit to Latest Update restricts retrieval to documents which were most recently added to the database. New documents are added to the Derwent Drug file at regular intervals.
Local Holdings Sentence Syntax: limit 1 to local holdings
  A limit to local holdings will restrict retrieval to documents from journals held in your local library or library system. If your System Administrator has created any special messages about a journal's availability, this message will display with the document in the Local Holdings (LH) field.
Male Sentence Syntax: limit 1 to male
  A limit to Male restricts retrieval to documents which are about males, both human and animal.
Ovid Full Text Available Sentence Syntax: limit 1 to ovid full text available
  A limit to Ovid Full Text Available will restrict retrieval to those citations for which an Ovid full text link is available.
Profile Section Sentence Syntax: limit 1 to agriculture
  A limit to Profile Section restricts retrieval to any of the profile subjects available from Derwent.
Publication Year Sentence Syntax: limit 1 to yr="2003"
Limit 1 to yr="2001 - 2003"
  A limit to Publication year restricts retrieval to any of the years covered in the database.
Reviews Sentence Syntax: limit 1 to reviews
  A limit to Reviews restricts retrieval to any of the years covered in this database.
Thematic Group Sentence Syntax: limit 1 to analysis
  A limit to Thematic Group restricts retrieval to any of the Thematic Groups available from Derwent.
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Tools
The following Search Tools are available for this database. For specific information on using these tools, refer to the Ovid Online Help linked below.
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Changing to this Database
To change a search session to a segment of this database from another database or another segment, use the following syntax in the Ovid Syntax tab:
  Command Syntax: ..c/derd
  Sentence Syntax: use derd

 

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Sample Document
Sample 1
Accession Number:
	2016-37083
Author:
	Takanashi N, Suzuki K, Kitajima M, Takayama H
Title:
	Total synthesis of conolidine and apparicine.
Source:
	Tetrahedron Lett. (57, No. 3, 375-8, 2016)
Corporate Information:
	Univ.Chiba
    	Chiba, Japan
Corporate Affiliates:
	Univ.Chiba
Location of Corporation:
	Chiba, Japan
Abstract:
	Total synthesis of indole alkaloids, (+/-)-conolidine (1) and (+/-)-apparicine (2) in 10 and 12 steps respectively 
    	from (E)-3-ethylidene 1-(2-nitrophenylsulfonyl) piperidine 4-carbaldehyde (5) and 2-lithio benzenesulfonyl 
    	indole (4) are reported. Coupling of (5) with (4) in THF at -78 deg, followed by oxidation of the resulting 
    	secondary alcohol with Dess-Martin periodinane gave (S,E)-(3-ethylidene 1-(2-nitrophenylsulfonyl) 
   	piperidin-4-yl) (1-(phenylsulfonyl) 1H-indol 2-yl)methanone (15). Reaction of (15) with KOH in methanol at 
    	reflux temperature, followed by deprotection of 2-nitrophenylsulfonyl (Ns) group with PhSH in one pot afforded 
    	Micalizio's intermediate (3). Reaction of (3) with paraformaldehyde and (+)-CSA gave (1) in 59% yield. 
    	1,2-Addition reaction of (1) with methyl lithium followed by subsequent dehydration with trifluoroacetic acid 
    	gave (2) in 52% yield from (1).
   
43 Refs. Reprint Address: Chiba Univ, Grad Sch Pharmaceut Sci, 1-8-1 Inohana, Chiba, Japan, 2608675. (Takayama H, e-mail: [email protected]). Common Terms: TOTAL/FT, SYNTH./FT, RACEMIC/FT Linked Terms: 1: CONOLIDINE/OC, NEW/FT, ANALGESICS/FT, OC/FT 2: PERICALLINE/OC, NARCOTICS/FT, OC/FT Derwent Registry Name: DR4004436, PERICALLI Thematic Groups: Chemistry Profile Sections: Analgesics (post 1985), Medicinal Chemistry, New Drugs Subject Headings: TOTAL/ft[Further Terms] SYNTH./ft[Further Terms] RACEMIC/ft[Further Terms] CONOLIDINE/oc[Other Context] NEW/ft[Further Terms] ANALGESICS/ft[Further Terms] OC/ft[Further Terms] PERICALLINE/oc[Other Context] NARCOTICS/ft[Further Terms] ISSN: 0040-4039 Language: English CODEN: TELEAY Date Delivered: 20161125 Year: 2016 Update Code: 201648

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Sample 2
Accession Number:
	2000-35108
Author:
	Gervelas C, Avramoglou T, Crepin M, Chaubet F, Jozefonvicz J
Conference Information:
	20th Forum on Cancer Study, Paris, France, 2000
Title:
	The effect of sodium phenylacetate and dextran derivatives on the tumor cell line 1205LU. (Fr.).
Original Title:
	Effet du phenylacetate de sodium et de derives du dextrane sur la lignee cellulaire tumorale 1205LU.
Source:
	Bull.Cancer (87, No. 5, 413-14, 2000)
Corporate Information:
	Univ.Paris
    	Villetaneuse; Bobigny, Fr.
Corporate Affiliates:
	Univ.Paris
Location of Corporation:
	Villetaneuse; Bobigny, Fr.
Abstract:
	This study showed that high doses of sodium phenylacetate (SP) and substituted dextran derivatives had antiproliferative
    	effects in 1205 LU human melanoma tumor cells in-vitro. At concentrations achieved in-vivo, SP had no antiproliferative
        effects. Semisynthetic dextrans with methylcarboxylate (MC) and benzylamide (B) substituent (DMCB-type dextrans) had
        antiproliferative effects and inhibited cell adhesion. An in-vivo study with the most active derivative is under way to study 
        the effects of these agents on tumor growth and angiogenesis.

In human 1205LU tumor melanoma cells, which form nodules in-vitro that resemble the chemorefractory tumors observed in the lungs of athymic mice, high doses of SP (12-18 mM) exhibited a dose-dependent antiproliferative effect. No antiproliferative effects were achieved at physiological concentrations of SP (1 mM or less). The DMCB-type dextran derivatives had an antiproliferative effect of about 20% at concentrations above 100 ug/ml. Studies with matrigel suggested these DMCB derivatives also inhibited cell adhesion. Reprint Address: LRM, CNRS UMR 7540, Institut Galilee, Universite Paris 13, avenue J.-B.-Clement, 93430 Villetaneuse, France. Linked Terms: 1: PHENYLACETATE/PH, SODIUM/PH, TUMOR-CELL/FT, IN-VITRO/FT, SODIUM-SALT/FT, CYTOSTATIC/FT, DOSAGE/FT, HIGH/FT, ADHESION/FT, DER./FT, MELANOMA/FT, 1205LU-CELL/FT, TISSUE-CULTURE/FT, PH/FT Derwent Registry Name: PHENYLACE Thematic Groups: Pharmacology Profile Sections: Chemotherapy - non-clinical Subject Headings: PHENYLACETATE/ph[Pharmacology] SODIUM/ph[Pharmacology] TUMOR-CELL/ft[Further Terms] IN-VITRO/ft[Further Terms] SODIUM-SALT/ft[Further Terms] CYTOSTATIC/ft[Further Terms] DOSAGE/ft[Further Terms] HIGH/ft[Further Terms] ADHESION/ft[Further Terms] DER./ft[Further Terms] MELANOMA/ft[Further Terms] 1205LU-CELL/ft[Further Terms] TISSUE-CULTURE/ft[Further Terms] PH/ft[Further Terms] ISSN: 0007-4551 Language: French CODEN: BUCABS Date Delivered: 20000920 Year: 2000 Update Code: 200000
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